Name | Dichlorophenyl-ABA |
Synonyms | Dichlorophenyl-ABA benzoic acid, 2-[(3,5-dichlorophenyl)amino]- |
CAS | 18201-65-5 |
Molecular Formula | C13H9Cl2NO2 |
Molar Mass | 282.12 |
Density | 1.470±0.06 g/cm3(Predicted) |
Melting Point | 245 °C |
Boling Point | 420.8±45.0 °C(Predicted) |
Solubility | DMSO: ~18mg/mL at~60°C |
Appearance | solid |
Color | white |
pKa | 3.62±0.36(Predicted) |
Storage Condition | 2-8°C |
In vitro study | Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
biological activity | Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, more than 80% of aggregate formation was inhibited in cells expressing TTR L55P. |
Target | transtiretin (TTR) amyloid fibril formation |